Neurofilament Light Chain in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a disease affecting nerve cells in the brain and spinal cord, leading to muscle weakness. This study examines neurofilament light chain (NfL) in the blood of ALS patients to understand the disease better. NfL is a protein that can show nerve cell damage. Researchers want to see how NfL levels relate to how quickly ALS gets worse, how long it lasts, and if it affects breathing. They will study 3,000 ALS patients using a special test called Single Molecule Analysis (SIMOA) to measure NfL levels. The study will also look at different types of ALS based on which nerves are affected or how the disease spreads in the body. To join, you must be at least 18 years old, diagnosed with ALS, agree to give blood samples, and allow your data to be used.

• Study involves multiple visits for blood collection.
• No direct treatment is provided; it’s for research purposes.
• Participation helps improve understanding of ALS progression.