Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failure

Premature Ovarian Failure (POF) is when a woman's ovaries stop working before she turns 40. This can cause menstrual problems like no periods (amenorrhea) or fewer periods (oligomenorrhea). In this study, doctors are using a special kind of treatment called **MSC-EVs**. These are tiny bubbles from cells that could help the ovaries start working again. The study wants to see if this treatment is safe and if it helps women with POF.

To be part of this study, women must be between 20 and 38 years old and should have normal genetic tests. Women with certain diseases or who had ovarian tumors can't join. If you're chosen, you'll have a special injection into the ovary, and doctors will check your health for 8 months to see how your body reacts. They'll look at hormone levels and check if your periods come back.

• The study lasts for 8 months with regular check-ups.
• Participants will get an injection of MSC-EVs.
• Doctors will monitor for any side effects, like fever or infection.