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Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failure

Testing new treatment for early ovarian failure with special cell injections.

Recruiting
20-38 years
Female
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

Premature Ovarian Failure (POF) happens when a woman's ovaries stop working before she's 40, causing periods to stop or become irregular. This study is testing a new treatment with special particles called Mesenchymal Stromal Cells-derived Extracellular Vesicles (MSC-EVs), tiny bubbles from cells that may help ovaries work better without causing harm. Extracellular Vesicles (EVs) are like tiny packages that cells send out to communicate. The study will look at whether these injections can help women with POF regain their menstrual cycles and improve hormone levels like Follicle-Stimulating Hormone (FSH) and Anti-Mullerian Hormone (AMH).

Key Points:

  • Participants will be observed for 8 months to check for improvements and any side effects.
  • Women aged 20-38 with POF and normal tests can join; those with certain health issues cannot.
  • Injections will be given after stopping hormone therapy for at least two months.

The study aims to improve fertility options for women facing early ovarian failure, with careful monitoring to ensure safety. 🩺📅

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Study details
    Premature Ovarian Failure

NCT06202547

Royan Institute

24 January 2024

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