The study looks at how the tiny organisms in our gut (gut microbiome) and certain chemicals in our blood (serum metabolites) may cause pain in people who have had a kidney transplant. About half of these patients feel ongoing pain after their transplant, which can make them tired and anxious, and stop them from doing fun activities. The study will explore how diet and stress affect this pain. After a transplant, people's eating habits change, which can impact the gut microbiome. Stress can also change how the microbiome works, possibly causing more pain.

• Study Length: This is a long-term study with repeated observations to see changes over time.
• Participation Requirements: Participants must be adults having a kidney transplant at the University of Illinois.
• Exclusions: Cannot participate if taking high doses of certain medications or have specific medical histories.

By understanding these connections, scientists hope to find better ways to treat pain in kidney transplant patients.