Organ Preservation First Strategy and Intentional Watch and Wait for MRI Defined Low-risk Rectal Cancer

This clinical trial is for adults aged 18 to 85 with a specific type of rectal cancer. The study focuses on patients whose cancer is considered low-risk based on MRI scans. The main goal is to see if we can safely avoid major surgery by using local excision (LE) or choosing not to operate (NOM) after treating the cancer with special radiation therapy and medicines like capecitabine and CapeOX. **Local excision** is when only the cancerous part is removed, and **non-operative management** means carefully watching the cancer without immediate surgery. Participants might get different treatments based on how their cancer responds to the initial therapy.

• Participants need to visit for regular check-ups, and the study might require some specific treatments or procedures.
• There are risks, like with any medical treatment, but the goal is to provide less invasive options.
• Participants will need to meet certain health criteria and agree to the study terms.

If you're interested, it's important to have a detailed discussion with your doctor to see if this study is a good fit for you. 😊