The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

This study tests a new way to help very sick patients breathe better while using a machine called a ventilator in the ICU (Intensive Care Unit). The study compares two methods of sedation, which is when medicine is used to help patients stay calm or asleep. One method uses a special measuring tool called **P0.1** to check breathing strength, along with a known checklist (RASS) to check how awake the patient is. P0.1 measures how hard a patient starts a breath. The other method only uses the checklist. Patients will be watched closely to see which method helps them get off the ventilator faster and recover better. If you join, you will be randomly placed in one of these two groups and monitored for 48 hours. The researchers need adults in the ICU who have been on a ventilator for less than 72 hours due to sudden breathing problems. They're not including people with other conditions like after surgery, certain brain problems, or severe liver issues.

• Study lasts 48 hours, with close monitoring of sedation and breathing.
• No extra visits needed; occurs during your ICU stay.
• Eligibility depends on recent mechanical ventilation due to sudden breathing issues.