This study is for patients who need help breathing with a machine in the ICU (Intensive Care Unit). It's about testing a new way to give medicine that makes you sleepy, called sedation. **Sedation** helps patients feel calm, and this study wants to see if using a special measure called **P0.1** (which checks how hard you breathe against the machine) along with a score called **RASS** (Richmond Agitation-Sedation Scale that checks how awake you are) helps more than just using RASS alone. Patients will be split into two groups. One group will have their sedation adjusted using both P0.1 and RASS, and the other group will use only RASS. They will be checked for 48 hours to see which way works better.

• Study lasts 48 hours for each patient.
• Patients must be at least 18 years old and in the ICU needing a breathing machine.
• Some people cannot join, like those with certain health problems or who are pregnant.