This study wants to see if a new way of giving radiation called **carbon ion radiotherapy** can help patients with a type of lung cancer called **non-small cell lung cancer (NSCLC)** that can't be removed by surgery. In this study, patients will get radiation to their whole tumor, but one group will get extra radiation to a special part of the tumor that doesn't get enough oxygen (called **hypoxic lesions**). These areas are found using a special scan called **18F-Misonidazole PET/CT**. The study will compare how long the cancer stays away and other health outcomes between the two groups. **Key Points**: - The study will last for a specific treatment period with follow-up visits afterward. - Participants need to have specific health conditions and must **sign a consent form**. - There are possible side effects and risks related to radiation therapy that will be monitored. **Eligibility**: Adults aged 18-80 with certain lung cancer conditions can join. People with other severe health issues, certain past treatments, or who are pregnant cannot participate.