Randomized Study of Carbon Ion Boost in Hypoxic Lesions for Locally Advanced Non-small Cell Lung Cancer

This study is testing a new way to treat *locally advanced non-small cell lung cancer (NSCLC)*. Researchers are seeing if adding extra carbon ion radiotherapy to areas of the tumor that don't get enough oxygen (hypoxic lesions) can improve outcomes compared to the standard treatment. Carbon ion radiotherapy is a special type of treatment that uses charged carbon particles to target cancer cells. During the study, patients will be split into two groups. One group will get the standard carbon ion treatment, while the other will get extra doses to those low-oxygen spots. The study aims to see if this approach helps patients live longer without the cancer getting worse. Participants have to be between 18 and 80 years old and meet specific health criteria. This means they can’t have certain other health conditions or treatments that might interfere with the study.

• Participants will be randomly placed into one of the two treatment groups.
• The study involves 22 treatment sessions.
• Participants must be able to understand and sign the consent form.