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FOLFOX-HAIC Plus Lenvatinib and Toripalimab vs. FOLFOX-HAIC Plus Lenvatinib for Advanced Hepatocellular Carcinoma: a Randomized Controlled and Double-blind Trial

Trial comparing two treatments for advanced liver cancer.

Recruiting
18-75 years
All
Phase 3
Study Overview: This study is testing treatments for advanced liver cancer called hepatocellular carcinoma (HCC). It compares two groups: one receiving a treatment mix called FOLFOX-HAIC with two drugs, lenvatinib and toripalimab, and another receiving FOLFOX-HAIC with just lenvatinib. FOLFOX-HAIC is a type of chemotherapy given directly into the liver, while lenvatinib and toripalimab are medications that help the immune system fight cancer. Eligibility: To join, patients need a specific liver cancer diagnosis and meet certain health criteria, like no prior treatment and good liver function. They should also understand the study and agree to participate. Important Points:
  • Participants must have advanced liver cancer with measurable tumors.
  • The study requires no previous liver cancer treatments.
  • Participants with hepatitis B can join if they receive antiviral therapy.
This study helps understand if adding toripalimab to the treatment improves outcomes compared to lenvatinib alone.
Study details
    Hepatocellular Carcinoma

NCT06201065

Sun Yat-sen University

24 January 2024

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