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SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma

Comparing two radiation therapies for recurring prostate cancer.

Recruiting
18 years and older
Male
Phase 3

This study compares two types of radiation treatments for men with prostate cancer that has come back or spread to a few places. Stereotactic Body Radiation Therapy (SBRT) and Hypofractionated Radiotherapy (HFRT) are the focus. SBRT uses special machines to aim radiation very precisely at the cancer, while HFRT gives higher doses over a shorter time. The goal is to see if SBRT works as well as HFRT but with a shorter treatment time and possibly fewer side effects.

  • Patients will be randomly placed in one of two groups: SBRT for 1-2 weeks or HFRT for 4-6 weeks.
  • Both groups may receive androgen deprivation therapy (ADT) for up to 18 months.
  • Regular follow-ups are required until 5 years after treatment, then every other year.

Participants must have had prostate surgery and meet specific health criteria. Those with certain past treatments or health issues are not eligible. This study helps determine which radiation method is better for treating prostate cancer that has returned or spread.

Study details
    Biochemically Recurrent Prostate Carcinoma
    Oligometastatic Prostate Carcinoma
    Recurrent Prostate Adenocarcinoma
    Stage IIB Prostate Cancer AJCC v8
    Stage IIC Prostate Cancer AJCC v8
    Stage III Prostate Cancer AJCC v8
    Stage IV Prostate Cancer AJCC v8

NCT06205316

Mayo Clinic

24 January 2024

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