This study compares two types of radiation treatments for men with prostate cancer that has come back or spread to a few places. Stereotactic Body Radiation Therapy (SBRT) and Hypofractionated Radiotherapy (HFRT) are the focus. SBRT uses special machines to aim radiation very precisely at the cancer, while HFRT gives higher doses over a shorter time. The goal is to see if SBRT works as well as HFRT but with a shorter treatment time and possibly fewer side effects.
- Patients will be randomly placed in one of two groups: SBRT for 1-2 weeks or HFRT for 4-6 weeks.
- Both groups may receive androgen deprivation therapy (ADT) for up to 18 months.
- Regular follow-ups are required until 5 years after treatment, then every other year.
Participants must have had prostate surgery and meet specific health criteria. Those with certain past treatments or health issues are not eligible. This study helps determine which radiation method is better for treating prostate cancer that has returned or spread.