Study Overview: This study is about finding out how well two medicines, irbesartan and eplerenone, work for people who have high blood pressure and are obese. Researchers will use a method called urinary proteomics to look at proteins in urine to predict how well these medicines will help lower blood pressure.
Key Points:
- Study lasts 8 weeks with two visits: one at the start and a follow-up after 8 weeks.
- Participants will take either irbesartan (150mg) or eplerenone (25mg twice a day).
- Eligible participants must have high blood pressure and be obese (BMI 30-39.99).
Details: The study will use a technique called LC-MS/MS to look at proteins in urine. Participants will be checked for blood pressure changes to see if they respond well to the medicine. Those who show a good response will be noted, and their urine samples will be studied to find markers that indicate successful blood pressure treatment.
Before joining, participants need to sign a consent form after understanding potential risks and benefits. This study is approved by an ethics board, ensuring safety and confidentiality of participants.