This study looks at the safety of a treatment called **Allocetra-OTS** for people with severe knee osteoarthritis, a condition where the knee joint is very worn out causing pain and difficulty moving. The study will check if this treatment can help and if it's safe to use. You can join if you are 18 or older, have severe knee osteoarthritis, and are set to have surgery. You must have a positive X-ray and normal blood tests. You cannot join if you have an infection in your knee, have had knee surgery, or have other serious health issues.
- **Study Length:** You will be followed for the duration of the study.
- **Visits Needed:** There will be multiple visits to monitor your health.
- **Risks:** May include pain, swelling, or infection.