Melasma is a skin condition that causes dark patches and can affect how people feel about themselves. This study looks at using oral isotretinoin (a medicine taken by mouth) to treat melasma. Oral isotretinoin has not been tried for melasma yet. The study will compare this to the usual treatment, which is a topical triple combination formula (a cream applied to the skin). We want to see how well isotretinoin works and if it's easy for people to take.
- The study is open to people aged 18-50 with melasma.
- Participants cannot be pregnant or breastfeeding.
- Women in the study must use two types of birth control.
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