A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder

This study is testing a new medicine called **SP-624** for adults with Major Depressive Disorder (MDD), which is a serious mood condition. The study will compare how well SP-624 works against a fake treatment called a **placebo**. This is a Phase 2B trial, meaning it's in the middle stage of testing to check if the medicine is safe and effective.

**Eligibility**: You can join if you are between 18 and 65 years old, have moderate to severe MDD, and are generally healthy. You cannot join if you are pregnant, have certain mental health disorders like schizophrenia, or have serious heart issues.

• The study will last several weeks with multiple visits to the clinic.
• Participants may receive compensation for their time and travel.
• It involves taking the study medicine or a placebo and regular health checks.

Participating in this study can help researchers learn more about SP-624 and possibly help others with depression in the future. If you think you meet the requirements, talk with your doctor to see if joining this study is a good choice for you.