Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention

Study on Depression and Suicidal Thoughts: This study looks at using a medicine called **esketamine** to help people with severe depression and thoughts of hurting themselves. After taking esketamine, some people will try **Cognitive Behavioral Therapy (CBT)**, which is a type of talk therapy using computers. Others will continue with their usual treatment (**TAU** - Treatment As Usual). We want to see if CBT helps people feel better for longer after using esketamine.

Who can join? Adults aged 18-65 who have depression and are in the hospital due to suicidal thoughts can join if a doctor recommends esketamine. They must not have certain other health issues, and they need to be willing to participate in the study activities.

• 📅 **Study Length**: Participation involves multiple visits over time.
• 💉 **Treatments**: Esketamine and possibly CBT.
• 📈 **Goal**: To check if CBT helps reduce suicidal thoughts better than usual treatments after esketamine.