This study is about finding new ways to treat depression, especially for people who can't feel pleasure (anhedonia) and have high inflammation. It's an 8-week *double-blind* study, which means neither the doctors nor the participants know who gets the real medicine (L-DOPA) or a fake pill (*placebo*). The study looks at how L-DOPA, a medicine used to treat brain problems, might help people with depression. Participants will do lab tests, answer questions about their feelings, and have brain scans (*MRI*). The whole process might take about 10-12 weeks. **Key Points:** - Study lasts 8 weeks, but participation can extend to 12 weeks. - Participants undergo lab tests, assessments, and MRI scans. - L-DOPA or placebo is randomly given, with no guarantee of which one you'll receive. To join, you need to be between 25-55 years old and have certain health conditions. You should not have specific health problems or be taking certain medications. If you're interested, you need to stop any mental health treatments for a few weeks before starting.