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Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD

Testing COMP360's effects for treatment-resistant depression (TRD) safety and effectiveness.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This research is testing a new treatment called **COMP360** for people with treatment-resistant depression (TRD). TRD means a person has tried at least two different medicines for depression, but they didn't help. The study is double-blind, so neither the doctors nor participants know who gets which dose. The study will last up to 16 weeks, including a screening period and follow-up. Participants will be randomly given one of three doses of COMP360 and psychological support, which is therapy to help with feelings and thoughts. The goal is to see if COMP360 can improve depression symptoms.

  • Duration: Up to 16 weeks with multiple visits.
  • Eligibility: Adults 18+ with TRD and no severe psychiatric disorders.
  • Risks: Participants must stop some medications before the study.

To join, you should be 18 years or older and have tried other depression treatments without success. Some people with certain mental health conditions can't join, like those with bipolar disorder or recent psychiatric hospital stays. Participants will need to stop certain medications before starting the study.

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Study details
    Treatment Resistant Depression

NCT05711940

COMPASS Pathways

8 July 2024

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