Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder
Recruiting
18-65 years
Both
Phase 3
This study looks at how a new medicine called NMRA-335140 helps people with Major Depressive Disorder (MDD). MDD is a serious type of depression. The study is "double-blind", meaning neither the participants nor the researchers know who is getting the real medicine or a "placebo" (a harmless pill). The study lasts 6 weeks, but it starts with a "Screening Period" that can last up to 35 days to make sure participants fit the study rules. Participants may continue with the medicine in an "open-label extension", where everyone knows they are getting NMRA-335140, if they meet certain criteria.
To join, participants should have a doctor-confirmed diagnosis of MDD, with symptoms lasting over 4 weeks but less than a year. They should not have certain other mental health conditions or be actively suicidal. People who have not responded to at least two antidepressants in the past may not join.
- Study requires six weeks of participation, with additional screening time.
- Participants may get a placebo instead of the actual medicine.
- Potential to continue treatment in an extension study if criteria are met.
Study details
Major Depressive Disorder
NCT06058039
Neumora Therapeutics, Inc.
8 July 2024
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Study Definition
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