A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight

This study checks how well a medicine called **retatrutide** works for people who are overweight or have obesity. It's also looking at groups with knee **osteoarthritis** (joint pain) and **obstructive sleep apnea** (breathing pauses during sleep). The study will last about 89 weeks, with up to 24 visits. To join, you must have a **body mass index (BMI)** of at least 30, or 27 with other health issues like high blood pressure or heart disease. You must have tried to lose weight before without success. You can't join if your weight changed a lot recently or if you have diabetes or have taken weight loss drugs recently. If you have knee pain, you must meet certain criteria based on pain and X-rays. For sleep apnea, you must have been diagnosed before and meet specific conditions regarding treatment.

• Study lasts 89 weeks with up to 24 visits.
• No recent weight loss drugs or major weight changes.
• Specific conditions for knee pain and sleep apnea participants.