Study Objective: This study will look at how a combination of two drugs, naltrexone and bupropion, affects heart health. The goal is to see if these drugs increase the chance of serious heart problems, called Major Adverse Cardiovascular Events (MACE), compared to a placebo, which is a substance with no active medicine.
Details: Participants will be randomly divided into two groups. One group will take the study drugs, while the other will take a placebo. Both groups will also receive advice on losing weight through a lower-calorie diet and more physical activity. The study is double-blinded, meaning neither the participants nor the researchers know who is getting which treatment to ensure unbiased results.
Eligibility: Adults 18 years or older with a Body Mass Index (BMI) of 30 or more (obese) or 27 or more (overweight with health issues like diabetes or high blood pressure) may qualify. Certain conditions such as recent heart attack, uncontrolled blood pressure, or severe kidney/liver issues may disqualify participants.
- Study length and visits will be explained during the informed consent process.
- Participants must not use other weight loss drugs or have certain health issues.
- Daily use of a mobile app to record health information is required.
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