The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Study Purpose: This research aims to find out if a medicine called retatrutide can help reduce serious heart issues or stop kidney problems from getting worse in adults with obesity (BMI of 27 or more) and heart or kidney disease. The study will last about 5 years with about 27 doctor visits.

Key Terms: BMI is Body Mass Index, a measure of body fat based on height and weight. Atherosclerotic Cardiovascular Disease (ASCVD) is a condition where arteries become narrow or blocked. Chronic Kidney Disease (CKD) means the kidneys are damaged and can't filter blood well.

• The study lasts 5 years with 27 clinic visits.
• Participants may not have certain heart or kidney conditions.
• Compensation is not mentioned, but check with the study team.

Eligibility: Participants should be adults with a BMI of 27 or higher, may or may not have type 2 diabetes, and have heart or kidney disease. Exclusions: Those with type 1 diabetes, recent heart problems, severe heart failure, certain kidney conditions, or other specific medical histories are not eligible.