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A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

Research on Retatrutide for overweight or obese Type 2 Diabetes patients.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at how effective and safe retatrutide is for people with **Type 2 Diabetes** (T2D), who are also **obese** (very overweight) or **overweight** (above healthy weight). The study lasts about 89 weeks and includes up to 24 visits to the study site. Some participants may also have **Obstructive Sleep Apnea** (OSA), a condition where breathing stops and starts during sleep.

Eligibility: You can join if you have a **Body Mass Index (BMI)** of 27 or higher, stable T2D treatment for at least 90 days, and have tried to lose weight before. If you have OSA, additional criteria apply, like being unable or unwilling to use **Positive Airway Pressure** (PAP) therapy.

  • Duration: The study lasts about 89 weeks with up to 24 visits.
  • Compensation: Participants may receive compensation for their time and travel.
  • Risks: May include side effects from retatrutide or sleep study procedures.

Not eligible if you have a recent weight change over 11 pounds, use weight loss drugs, or have Type 1 diabetes.

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Study details
    Type 2 Diabetes
    Obesity
    Overweight
    Obstructive Sleep Apnea

NCT05929079

Eli Lilly and Company

2 December 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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