Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a genetic condition that affects the brain's blood vessels, leading to cognitive issues like dementia. This study aims to understand how CADASIL progresses and the factors influencing it. The study will include 500 participants with a family history of CADASIL and will last up to five years. Participants will undergo tests, including brain scans (MRI), blood tests, and cognitive assessments, over three in-person visits (initial, 18 months, and 36 months later). They will also have remote check-ins via phone or email.

• Participants will have three in-person visits over three years.
• All medications are allowed, but must be documented.
• Participants will need a "study companion" who knows them well.

Eligible participants must be 18 or older, willing to undergo genetic testing, and have no severe learning disabilities or drug abuse history. If you meet these criteria and want to help advance the understanding of CADASIL, consider joining this study! 🧠💉