**The CHRONICLE Study** focuses on adults in the U.S. who have severe asthma and struggle to control it with high-dose inhaled corticosteroids (ICS) and other treatments. This study is *observational*, meaning it doesn't change how patients are treated but monitors their asthma over time. The study will follow at least 1,500 patients for at least three years, collecting data from doctors and patients using online surveys. These surveys will track asthma control, treatment effectiveness, and quality of life. *Key Points:* - **Length**: Patients will be followed for at least 3 years. - **Participation**: Monthly web-based surveys are required. - **Focus**: It’s observational, so no new treatments are provided. **Eligibility**: Participants must be 18 or older, have severe asthma for at least a year, and be under a specialist's care. They need to have uncontrolled asthma despite high-dose ICS or be on systemic treatments like corticosteroids or monoclonal antibodies. Participants must be fluent in English or Spanish and able to complete online surveys.