Study of Iopofosine I 131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia

This study is about testing a new treatment called Iopofosine I 131 (CLR 131) for some types of blood cancers, including a specific type called Waldenstrom Macroglobulinemia (WM). Blood cancers happen when cells in your blood grow in a way they're not supposed to. This study is divided into two parts. Part A is for people with different kinds of blood cancers who didn't get better with regular treatments. Part B focuses on people with WM who have tried at least two other treatments.

Iopofosine I 131 is a special kind of medicine that uses a tiny bit of radioactive material to try to kill cancer cells. The radioactive part, called iodine-131 (I-131), has been used before in other cancers. This study wants to see if it can help people with WM.

• You need to have tried at least two other treatments for WM to join.
• The medicine is given through an IV (a needle in your vein).
• There may be risks because of the radioactivity, so it's important to talk to your doctor.