**Study Overview:** This study is about collecting tissue samples (such as blood, urine, or tumor tissue) from cancer patients for research. The samples help scientists learn more about cancer. Adults and children who are getting care for cancer at the NIH Clinical Center or other participating sites can join. **Key Points:** - **Duration:** You stay in the study based on your consent or until the planned procedures are done. - **Procedures:** Some samples might be collected during your regular medical care, while others may need extra non-surgical procedures, like a biopsy. Discuss any risks with your doctor. - **Consent:** You need to sign a form to agree to participate. For children, parents or guardians must also agree. **Important Information:** - **Eligibility:** Both adults and children with a confirmed cancer diagnosis can participate. Some restrictions apply, like no participation if you have an active infection. - **Risks:** Some procedures, like biopsies, might have risks, which will be explained in detail beforehand. - **Purpose:** The study aims to support research to develop new cancer treatments and understand the disease better. Please discuss with your doctor if you're interested in participating.