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Bicalutamide Therapy in Young Women With NAFLD and PCOS

Exploring bicalutamide for young women with NAFLD and PCOS.

Recruiting
18-42 years
Female
Phase 1
**Study Summary:** This study is testing a medicine called bicalutamide in young women with two conditions: NAFLD (Nonalcoholic Fatty Liver Disease) and PCOS (Polycystic Ovary Syndrome). NAFLD is when fat builds up in the liver, which can cause liver damage. PCOS involves hormone problems that can lead to irregular periods and other symptoms. The study wants to see if bicalutamide can help with liver problems in these women. The study will last for 6 months, and participants will take a daily dose of either bicalutamide or a placebo (a pill with no active medicine). **Key Points:** - **Duration and Visits:** The study runs for 6 months with monthly in-person visits and a phone check-up at the end. - **Eligibility:** Women aged 18-42 with PCOS and liver issues can join. Some health conditions will exclude participation, like uncontrolled diabetes or alcohol use. - **Risks and Benefits:** Participants should consider potential side effects and study demands.
Study details
    NAFLD
    PCOS

NCT05979389

University of California, San Francisco

9 September 2025

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