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Fine Needle aSpiration of Lymph nodEs to Study vAccine-induced Immunity

Studying vaccine effects using fine needle lymph node samples.

Recruiting
20-40 years
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study aims to understand how a vaccine called **Prevenar13** affects the immune system by studying the lymph nodes, which are small glands that help your body fight infection. **Fine Needle Aspiration (FNA)** is a technique used to take a small sample from the lymph nodes using a thin needle. This study will measure how the immune cells, specifically **germinal centre B cells (BGC)**, respond after vaccination.

Participants should be healthy adults aged 20-40. They will have 8 check-ups over three months, including blood tests and lymph node measurements. An ultrasound will be used to check the lymph node size. Eligible participants should not have certain health issues like infections, be pregnant, or have a high BMI.

  • Study involves 8 visits over three months.
  • Participants must be healthy and aged 20-40.
  • No compensation is mentioned for participation.
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Study details
    Vaccine-Preventable Diseases

NCT06202703

Leiden University Medical Center

24 January 2024

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