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Found 407 clinical trials

Respiratory Physiotherapy as a Tool to Increase the Number of Solid Organ Donors

The main objective of the project is to determine the variation of PaO2 / FiO2 (PaFi) after the use of mechanical insufflation-exsufflation (MI-E) or mechanical cough assistant in the donor in brain death (DBD) and in the potential donor in control donor after circulatory death (cDCD) It is a randomized …

18 years and older
All
Phase N/A

ITGA6 Targeting NIR-II Fluorescence Image Guided Surgery

In this study, the investigators will detect hepatocellular carcinoma lesions using fluoescence imaging with ITGA6 targeting probes during tumor resection surgery. The aim is to evaluate wether intraoperative fluorescence imaging targeting ITGA6 can help to improve the detction effect of hepatocellular carcinoma, and finally help the accurate surgical resection. The …

18-80 years
All
Phase 1

Use of Allocetra-OTS in End Stage Knee Osteoarthritis - Assessment of Safety

This is a pilot study to assess safety and possible efficacy of Allocetra-OTS in end-stage knee osteoarthritis.

18 years and older
All
Phase N/A

Intensive Neurowave Emotional Stimulation (INES)

This is a randomized and controlled pilot study investigating the effects of intensive emotional stimulation with neurological waves (INES) on cognitive-motor functions in patients diagnosed with Vegetative State (VS) and Minimally Conscious State (MCS) following severe brain injury. The study aims to enroll at least 20 patients aged between 18 …

16-65 years
All
Phase N/A

Effect of the LumbaCure® Intervention on Elderly Patients Suffering From cLBP.

The goal of this investigation is to evaluate the safety and efficacy of the LumbaCure® device in elderly people suffering from low back pain. The study is being carried out at several sites, in nursing homes, in order to reach the elderly patients most at risk of a sedentary lifestyle.

60 years and older
All
Phase N/A

Neoadjuvant Therapy of HAIC?GEMOX? Combined With Adebrelimab and Lenvatinib for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors?NEO-ERA-01 Study

Clinical Study on the efficacy and safety of hepatic arterial perfusion chemotherapy and Renvastinib combined with Adebrelimab neoadjuvant therapy for resection of high-risk biliary tract carcinoma.

18-75 years
All
Phase 2

Oral Isotretinoin in Melasma a Randomized Controlled Trial

Melasma is a common refractory acquired hyperpigmentation of the skin having a serious impact on patients' quality of life. Melasma is challenging to treat. Treatment is often a multimodality approach. Due to the attached psychological and social stress, it is important to counsel patients with melasma adequately about the chronicity …

18-50 years
All
Phase 1

Understanding and Intervening With State Shame and Self-criticism

The goal of this clinical trial is to compare the momentary effects of a one-session intervention (compassion-based, logic-based, or placebo control) on individuals with high or low trait self-criticism. The main questions it aims to answer are: After a momentary shame induction, will a compassion-based intervention and a logic-based intervention …

18 years and older
All
Phase N/A

Carbofix Pedicle Screw System: Evaluation of the Clinical and Radiographic Outcomes of the Use of a Carbon Fiber Device Compared to Titanium Devices in Patients Undergoing Spinal Arthrodesis for Degenerative Spinal Diseases

Previous clinical study carried out on cancer patients at IOR Spine Surgery (approved in October 2014). The carbon device is indicated in patients suffering from vertebral tumors who need stabilization and will then carry out radiotherapy, because carbon has a practically zero level of interference with ionizing radiation. Carbon also …

18 years and older
All
Phase N/A

Analgesia Nociception Index in Orthognathic Surgery

This study aims to determine whether goal-directed analgesia using ANI(Analgesia/Nociception Index) can improve the quality of postoperative recovery in patients undergoing maxillofacial surgery.

18 years and older
All
Phase N/A

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