Found 411 clinical trials
Clinical Study of TROP-2 PET/CT for Noninvasive Diagnosis of Solid Tumors
In this study, we will investigate the diagnostic efficacy and safety of [18F]F/[68Ga]Ga-NOTA-T4 in pancreatic cancer, breast cancer, or head and neck malignant tumors, and evaluate the sensitivity and specificity of using [18F]F/[68Ga]Ga-NOTA-T4 for diagnosing HCC. This study will provide a new method for the noninvasive target-specific diagnosis of pancreatic …
Depression and Suicide Prevention in Adolescents Attending Special Schools
Depression is a major public health concern. In Dutch adolescents, the prevalence of major depressive disorder is estimated at 3.8%, and one in five adolescents report depressive symptoms. Depression is a risk factor in adolescent suicide. School-based prevention programs, for example the STORM approach, are effective in decreasing depressive symptoms …
Phase II Study of Concurrent Radiotherapy With Envafolimab and Capecitabine in LAPC
This is a single-arm prospective phase II clinical trial to investigate the efficacy and safety of concurrent radiotherapy with envafolimab and capecitabine in locally advanced pancreatic cancer.Eligibility patients will receive intensity-modulated radiotherapy(IMRT)or volumetric modulated arc therapy(VMAT) to pancreatic lesions,metastatic lymph nodes and high-risk lymphatic drainage areas,concurrent with and followed by …
Phase II Study of Adjuvant SIB Radiotherapy Following Narrow-Margin Hepatectomy in Patients With HCC.
This is a single-arm prospective phase II clinical trial to investigate the efficacy and safety of adjuvant simultaneouslyintegrated boost radiotherapy following narrow-margin(<1cm) hepatectomy in patients with HCC. Eligibility patients will receive IMRT or VMAT to high risk area of tumor bed and tumor bed. The prescription dose to 95% GTVtb …
Romiplostim in Chemotherapy-Induced Thrombocytopenia
Prospective interventional randomized controlled trial to assess safety and efficacy of romiplostim in chemotherapy-induced thrombocytopenia in children and adolescents with solid malignancy
Feasibility and Effects of Laughter-imitation Therapy (LIT)
Background: The mental wellbeing of the institutional population has to be promoted, particularly after the serious hit by the pandemic. Objectives To develop a LIT intervention to promote mental wellbeing of institutional older adults To explore the feasibility and acceptability of such intervention; To explore the potential effect of the …
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis. The main question[s] it aims to …
Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer
This randomized controlled phase III trial aims to evaluate the use of electroacupuncture in combination with olanzapine-containing standard quadruple antiemetic drugs for the treatment of nausea and vomiting induced by highly emetogenic chemotherapy (HEC) in patients with breast cancer. Furthermore, it will analyze the relationship between single nucleotide polymorphism and …
BI-1910 as a Single Agent and in Combination With Pembrolizumab for the Treatment of Advanced Solid Tumors
The goal of this first in human clinical trial is to test BI-1910 administered as single agent and in combination with pembrolizumab in subjects with advanced/metastatic solid tumors whose disease has progressed after standard therapy. The main questions it aims to answer are: how safe and tolerable is BI-1910 what …
SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma
This phase III trial tests the side effects of stereotactic body radiation therapy (SBRT) compared to hypofractionated radiotherapy for treating patients with prostate adenocarcinoma that has come back after a period of improvement (recurrent) or that has spread from where it first started (primary site) to a limited number of …